The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Persistent androgen receptor (AR) transcriptional activity underlies resistance to AR-
targeted therapy and progression to lethal castration-resistant prostate cancer (CRPC) …

Abstract In the United States, prostate cancer (PCa) is the most commonly diagnosed non-
cutaneous cancer in males and the second leading cause of cancer-related death for men …

The normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …

Testosterone is one of the most potent naturally secreted androgenicanabolic hormones,
and its biological effects include promotion of muscle growth. In muscle, testosterone …

Therapy for advanced prostate cancer centers on suppressing systemic androgens and
blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels …

The androgen receptor (AR) plays a key role in progression to incurable androgen ablation–
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …