Exploring the potential of aptamers in targeting neuroinflammation and neurodegenerative disorders: Opportunities and challenges

AHY Kong, AJ Wu, OKY Ho, MMK Leung… - International Journal of …, 2023 - mdpi.com
Neuroinflammation is the precursor for several neurodegenerative diseases (NDDs), such
as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) …

Neurological complications of biological treatment of psoriasis

MK Ożóg, BO Grabarek, M Wierzbik-Strońska… - Life, 2022 - mdpi.com
In the available literature, little attention has been paid to the assessment of psoriasis and
the biological therapy used for it and the nervous system. The purpose of this article is to …

[HTML][HTML] Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related …

A Urban, D Sidorenko, D Zagirova, E Kozlova… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Aging is a complex and multifactorial process that increases the risk of various age-related
diseases and there are many aging clocks that can accurately predict chronological age …

Altered serum interleukin-17A and interleukin-23A levels may be associated with the pathophysiology and development of generalized anxiety disorder

ASM Roknuzzaman, R Sarker, J Nayem… - Scientific Reports, 2024 - nature.com
In recent times, the pathogenesis of generalized anxiety disorder (GAD) and the influence of
pro-and anti-inflammatory cytokines on it have garnered considerable interest. Cytokine …

Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction

Y Lu, X Chen, X Liu, Y Shi, Z Wei, L Feng, Q Jiang… - Autophagy, 2023 - Taylor & Francis
Cognitive impairment caused by systemic chemotherapy is a critical question that perplexes
the effective implementation of clinical treatment, but related molecular events are poorly …

Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic …

K Tylek, E Trojan, M Leśkiewicz… - ACS Chemical …, 2023 - ACS Publications
A substantial body of evidence demonstrates an association between a malfunction in the
resolution of acute inflammation and the development of chronic inflammation. Recently, in …

Molecular mechanisms of sulforaphane in Alzheimer's disease: Insights from an in-silico study

GH Vu, HD Nguyen - In Silico Pharmacology, 2024 - Springer
This study was to identify the molecular pathways that may explain sulforaphane's
Alzheimer's disease (AD) benefits using multiple advanced in silico approaches. We found …

Bisdemethoxycurcumin (BDC)-loaded H-ferritin-nanocages mediate the regulation of inflammation in Alzheimer's disease patients

S Gagliardi, M Truffi, V Tinelli, M Garofalo… - International Journal of …, 2022 - mdpi.com
Background: Bisdemethoxycurcumin (BDC) might be an inflammation inhibitor in
Alzheimer's Disease (AD). However, BDC is almost insoluble in water, poorly absorbed by …

The human microglia responsome: a resource to better understand microglia states in health and disease

GJLJ Snijders, K de Paiva Lopes, MAM Sneeboer… - bioRxiv, 2023 - biorxiv.org
Microglia, the immune cells of the brain, are increasingly implicated in neurodegenerative
disorders through genetic studies. However, how genetic risk factors for these diseases are …

IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy

JG Krueger, K Eyerich, VK Kuchroo… - Frontiers in …, 2024 - frontiersin.org
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory
cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis …