Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies

S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery

VK Singh, M Kalsan, N Kumar, A Saini… - Frontiers in cell and …, 2015 - frontiersin.org
Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …

An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells

K Okita, T Yamakawa, Y Matsumura, Y Sato… - Stem …, 2013 - academic.oup.com
The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use
patient-specific somatic cells, which are a valuable source for disease modeling and drug …

Genomic instability of iPSCs: challenges towards their clinical applications

M Yoshihara, Y Hayashizaki, Y Murakawa - Stem cell reviews and reports, 2017 - Springer
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly
from mature cells through the introduction of key transcription factors. iPSCs can be …

Induced pluripotent stem cells: the new patient?

M Bellin, MC Marchetto, FH Gage… - Nature reviews Molecular …, 2012 - nature.com
Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …

Induced pluripotent stem cells—opportunities for disease modelling and drug discovery

M Grskovic, A Javaherian, B Strulovici… - Nature reviews Drug …, 2011 - nature.com
The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

X Carvajal-Vergara, A Sevilla, SL D'Souza, YS Ang… - Nature, 2010 - nature.com
The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with
defined genetic disorders holds the promise of increased understanding of the aetiologies of …

Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells

T Seki, S Yuasa, M Oda, T Egashira, K Yae… - Cell stem cell, 2010 - cell.com
The direct reprogramming of somatic cells to produce induced pluripotent stem cells (iPSCs)
is a prominent recent advance in stem cell biology (Takahashi and Yamanaka, 2006) …

The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms

HC Hasselbalch, M Elvers… - Blood, The Journal of the …, 2021 - ashpublications.org
Thrombotic, vascular, and bleeding complications are the most common causes of morbidity
and mortality in the Philadelphia chromosome–negative myeloproliferative neoplasms …

Investigating human disease using stem cell models

JL Sterneckert, P Reinhardt, HR Schöler - Nature Reviews Genetics, 2014 - nature.com
Tractable and accurate disease models are essential for understanding disease
pathogenesis and for developing new therapeutics. As stem cells are capable of self …