The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …

Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …

Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …

Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus,
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

The skin is constantly exposed to exogenous and endogenous sources of reactive oxygen
species (ROS). An adequate balance between ROS levels and antioxidant defenses is …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

New insights into cancer cell–specific biological pathways are urgently needed to promote
development of rationally targeted therapeutics. Reactive oxygen species (ROS) and their …

BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …