Thioredoxin reductase inhibition for cancer therapy
R Gencheva, ESJ Arnér - Annual Review of Pharmacology and …, 2022 - annualreviews.org
The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
SS Sabharwal, PT Schumacker - Nature Reviews Cancer, 2014 - nature.com
Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …
Targeting the thioredoxin system for cancer therapy
Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …
[HTML][HTML] Role of selenoproteins in redox regulation of signaling and the antioxidant system: a review
Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus,
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …
Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling
EM Hanschmann, JR Godoy, C Berndt… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
[HTML][HTML] The double-edged sword of oxidative stress in skin damage and melanoma: From physiopathology to therapeutical approaches
M Emanuelli, D Sartini, E Molinelli, R Campagna… - Antioxidants, 2022 - mdpi.com
The skin is constantly exposed to exogenous and endogenous sources of reactive oxygen
species (ROS). An adequate balance between ROS levels and antioxidant defenses is …
species (ROS). An adequate balance between ROS levels and antioxidant defenses is …
From selenium to selenoproteins: synthesis, identity, and their role in human health
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …
has been known for several decades. This is attributed to low molecular weight selenium …
Reactive oxygen species: a breath of life or death?
JP Fruehauf, FL Meyskens Jr - Clinical Cancer Research, 2007 - AACR
New insights into cancer cell–specific biological pathways are urgently needed to promote
development of rationally targeted therapeutics. Reactive oxygen species (ROS) and their …
development of rationally targeted therapeutics. Reactive oxygen species (ROS) and their …
Focus on mammalian thioredoxin reductases—important selenoproteins with versatile functions
ESJ Arnér - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …
Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential
I Batinić-Haberle, JS Rebouças… - Antioxidants & redox …, 2010 - liebertpub.com
Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …