The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the
clinical management of gout and conditions associated with hyperuricemia for several …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Xanthine oxidoreductase (XOR) is a complex molybdoflavoenzyme, present in milk and
many other tissues, which has been studied for over 100 years. While it is generally …

cellular apoptosis signaling kinase-1, a redox-sensitive kinase upstream of Jun-nuclear
kinase and p38. Apoptosis signaling kinase-1 overexpression activates nuclear factor κB to …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Background—Serum uric acid (UA) could be a valid prognostic marker and useful for
metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF) …

Background—Impaired flow-dependent, endothelium-mediated vasodilation (FDD) in
patients with chronic heart failure (CHF) results, at least in part, from accelerated …

Allopurinol (ALP) attenuates oxidative stress and diabetic cardiomyopathy (DCM), but the
mechanism is unclear. Activation of nuclear factor erythroid 2‐related factor 2 (Nrf2) …

Background Dilated cardiomyopathy is characterized by an imbalance between left
ventricular performance and myocardial energy consumption. Experimental models suggest …

Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and
dysfunction. ROS contribute to this process. Here we show that uncoupling of nitric oxide …