Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and
are components of the innate immunity of almost all living things. They play an important role …

There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

Antimicrobial peptides (AMPs) are promising pharmaceutical candidates for the prevention
and treatment of infections caused by multidrug-resistant ESKAPE pathogens, which are …

The development of durable new antiviral therapies is challenging, as viruses can evolve
rapidly to establish resistance and attenuate therapeutic efficacy. New compounds that …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Antimicrobial peptides (AMPs) are natural biopolymers in the host defense system. AMPs
display multiple functions against bacterial, fungal, and viral infection, as well as anticancer …

Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that primarily infects
epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory …

Although persister cells are the root cause of resistance development and relapse of chronic
infections, more attention has been focused on developing antimicrobial agents against …

Human-derived antimicrobial peptides (AMPs), such as defensins and cathelicidin LL-37,
are members of the innate immune system and play a crucial role in early pulmonary …

The inherent capacity of all organisms to evolve under selective pressure has created
multidrug-resistant microbes and cells that are now threatening decades of progress in …