Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Telomere length shortens with age. Progressive shortening of telomeres leads to
senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health …

The natural ends of linear chromosomes require unique genetic and structural adaptations
to facilitate the protection of genetic material. This is achieved by the sequestration of the …

The mechanisms involved in the reprogramming of differentiated cells into induced
pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1) …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

Telomere shortening occurs concomitant with organismal aging, and it is accelerated in the
context of human diseases associated with mutations in telomerase, such as some cases of …

Increasing evidence indicates that chromatin modifications are important regulators of
mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin …

Telomere shortening is associated with organismal aging. iPS cells have been recently
derived from old patients; however, it is not known whether telomere chromatin acquires the …

Telomerase confers limitless proliferative potential to most human cells through its ability to
elongate telomeres, the natural ends of chromosomes, which otherwise would undergo …

Structure-specific endonucleases resolve DNA secondary structures generated during DNA
repair and recombination. The yeast 5′ flap endonuclease Slx1-Slx4 has received …