Amyloid-β plaques and neurofibrillary tangles (NFTs) are the 2 histopathologic hallmarks of
Alzheimer disease (AD). On the basis of the pattern of NFT distribution in the brain, Braak …

In vivo Alzheimer's disease diagnosis and staging is traditionally based on clinical features.
However, the agreement between clinical and pathological Alzheimer's disease diagnosis …

Next to amyloid and tau, synaptic loss is a key pathological hallmark in Alzheimer's disease,
closely related to cognitive dysfunction and neurodegeneration. Tau is thought to cause …

Background The ability of 18F-PI-2620 PET to measure the spatial distribution of tau
pathology in Alzheimer's disease (AD) has been demonstrated in previous studies. The …

Background The positron emission tomography (PET) radiotracer [18F] MK‐6240 exhibits
high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD) …

[18F] MK-6240 is a second-generation tau PET-tracer to quantify neurofibrillary tangles in-
vivo. However, individually variable levels of meningeal uptake induce spill-in-effects into …

We characterized the additive contribution of cerebrovascular biomarkers to amyloid and
neurodegeneration biomarkers (AV (N)) when modeling prospective, longitudinal cognitive …

Abstract Introduction Neocortical 3R4R (3‐repeat/4‐repeat) tau aggregates are rarely
observed in the absence of amyloid beta (Aβ). 18F‐MK6240 binds specifically to the 3R4R …

Tau deposition plays a critical role over cognition and neurodegeneration in Alzheimer's
disease (AD). Recent generation tracers have high target to background ratios giving a wide …

The progression of PET-based Braak stages correlates with cognitive deterioration in aging
and Alzheimer's disease. Here, we investigate the association between PET-based Braak …