Immune evasion and provocation by Mycobacterium tuberculosis

P Chandra, SJ Grigsby, JA Philips - Nature Reviews Microbiology, 2022 - nature.com
Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Immune cell interactions in tuberculosis

JAL Flynn, J Chan - Cell, 2022 - cell.com
Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …

Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in …

EB Irvine, A O'Neil, PA Darrah, S Shin… - Nature …, 2021 - nature.com
Abstract Development of an effective tuberculosis (TB) vaccine has suffered from an
incomplete understanding of the correlates of protection against Mycobacterium tuberculosis …

Latent tuberculosis: two centuries of confusion

MA Behr, E Kaufmann, J Duffin… - American journal of …, 2021 - atsjournals.org
The current dogma is that 2 billion individuals, making up a quarter of the world's population,
are latently infected with Mycobacterium tuberculosis (1–4). It is thought that latent …

[HTML][HTML] Human tuberculosis and Mycobacterium tuberculosis complex: A review on genetic diversity, pathogenesis and omics approaches in host biomarkers …

RD Kanabalan, LJ Lee, TY Lee, PP Chong… - Microbiological …, 2021 - Elsevier
Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Are we underestimating the annual risk of infection with Mycobacterium tuberculosis in high-burden settings?

DW Dowdy, MA Behr - The Lancet Infectious Diseases, 2022 - thelancet.com
The annual risk of infection with Mycobacterium tuberculosis determines a population's
exposure level and thus the fraction of incident tuberculosis resulting from recent infection …

Targeting innate immunity for tuberculosis vaccination

SA Khader, M Divangahi, W Hanekom… - The Journal of …, 2020 - Am Soc Clin Investig
Vaccine development against tuberculosis (TB) is based on the induction of adaptive
immune responses endowed with long-term memory against mycobacterial antigens …

Key advances in vaccine development for tuberculosis—Success and challenges

R Lai, AF Ogunsola, T Rakib, SM Behar - NPJ vaccines, 2023 - nature.com
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …

Accelerating research and development of new vaccines against tuberculosis: a global roadmap

F Cobelens, RK Suri, M Helinski… - The Lancet Infectious …, 2022 - thelancet.com
To eliminate tuberculosis globally, a new, effective, and affordable vaccine is urgently
needed, particularly for use in adults and adolescents in low-income and middle-income …

Initial immune response after exposure to Mycobacterium tuberculosis or to SARS-COV-2: similarities and differences

A Aiello, S Najafi-Fard, D Goletti - Frontiers in Immunology, 2023 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) and Coronavirus disease-
2019 (COVID-19), whose etiologic agent is severe acute respiratory syndrome coronavirus …