Cellular host factors for SARS-CoV-2 infection
Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …
and caused a global economic crisis. No effective antiviral drugs are currently available to …
Ebola virus disease
ST Jacob, I Crozier, WA Fischer, A Hewlett… - Nature reviews Disease …, 2020 - nature.com
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
Genetic screens identify host factors for SARS-CoV-2 and common cold coronaviruses
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …
Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks
WM Schneider, JM Luna, HH Hoffmann… - Cell, 2021 - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of
over one million people worldwide. The causative agent, severe acute respiratory syndrome …
over one million people worldwide. The causative agent, severe acute respiratory syndrome …
Bat-borne virus diversity, spillover and emergence
Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …
Lysosomal storage diseases
FM Platt, A d'Azzo, BL Davidson, EF Neufeld… - Nature reviews Disease …, 2018 - nature.com
Lysosomal storage diseases (LSDs) are a group of over 70 diseases that are characterized
by lysosomal dysfunction, most of which are inherited as autosomal recessive traits. These …
by lysosomal dysfunction, most of which are inherited as autosomal recessive traits. These …
Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2
The ongoing COVID-19 pandemic has caused a global economic and health crisis. To
identify host factors essential for coronavirus infection, we performed genome-wide …
identify host factors essential for coronavirus infection, we performed genome-wide …
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier
to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that …
to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that …
Accurate classification of BRCA1 variants with saturation genome editing
GM Findlay, RM Daza, B Martin, MD Zhang, AP Leith… - Nature, 2018 - nature.com
Variants of uncertain significance fundamentally limit the clinical utility of genetic information.
The challenge they pose is epitomized by BRCA1, a tumour suppressor gene in which …
The challenge they pose is epitomized by BRCA1, a tumour suppressor gene in which …
Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification in RNAs
and plays regulatory roles in a variety of biological and physiological processes. Despite its …
and plays regulatory roles in a variety of biological and physiological processes. Despite its …