Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …

Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …

Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …