The recognition of integrins as a widely expressed family of cell surface adhesion receptors
is around five years old (Hynes, 1987). At that time, one could identify about ten distinct …

Wound repair requires a continually evolving network of interactions among cells, cytokines
and the extracellular matrix. Cell-surface integrins provide a mechanical connection …

Papillomaviruses (PVs) bind in a specific and saturable fashion to a range of epithelial and
other cell lines. Treatment of cells with trypsin markedly reduces their ability to bind virus …

Extracellular matrix proteins and their cellular receptors, integrins, play a fundamental role in
keratinocyte adhesion and migration. During wound healing, keratinocytes detach, migrate …

BPAG1 is the major antigenic determinant of autoimmune sera of buIIous pemphigoid (BP)
patients. It is made by stratified squamous epithelia, where it localizes to the inner surface of …

Pyloric atresia associated with junctional epidermolysis bullosa (PA–JEB), is a rare inherited
disorder characterized by pyloric stenosis and blistering of the skin as primary …

Costameres, the vinculin-rich, sub-membranous transverse ribs found in many skeletal and
cardiac muscle cells (Pardo, JV, JD Siciliano, and SW Craig. 1983. Proc. Natl. Acad. Sci …

The corneal epithelium serves as a barrier and contributes to the maintenance of corneal
transparency and rigidity. In most instances, corneal epithelial defects caused by simple …

Previously, we demonstrated that proteolytic processing within the globular domain of the α3
subunit of laminin-5 (LN5) converts LN5 from a cell motility-inducing factor to a protein …

Functional studies on the α6β4 integrin have focused primarily on its role in the organization
of hemidesmosomes, stable adhesive structures that associate with the intermediate …