[HTML][HTML] Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications

K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …

[HTML][HTML] Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease

Y Zong, X Wang, B Cui, X Xiong, A Wu, C Lin, Y Zhang - Molecular Therapy, 2023 - cell.com
Non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and
circular RNAs (circRNAs), are being studied extensively in a variety of fields. Their roles in …

Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease

SG Cull‐Candy, M Farrant - The Journal of Physiology, 2021 - Wiley Online Library
AMPA receptors are tetrameric glutamate‐gated ion channels that mediate a majority of fast
excitatory neurotransmission in the brain. They exist as calcium‐impermeable (CI‐) and …

Discovery of targets for immune–metabolic antitumor drugs identifies estrogen-related receptor alpha

A Sahu, X Wang, P Munson, JPG Klomp, X Wang… - Cancer discovery, 2023 - AACR
Drugs that kill tumors through multiple mechanisms have the potential for broad clinical
benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer …

[HTML][HTML] The role and therapeutic implication of CPTs in fatty acid oxidation and cancers progression

J Wang, H Xiang, Y Lu, T Wu, G Ji - American Journal of Cancer …, 2021 - ncbi.nlm.nih.gov
Cancer cells must maintain metabolic homeostasis under a wide range of conditions and
meet their own energy needs in order to survive and reproduce. In addition to glycolysis …

Cascade-Responsive 2-DG Nanocapsules encapsulate aV-siCPT1C conjugates to inhibit Glioblastoma through multiple inhibition of Energy Metabolism

Y Zhang, Y Ren, H Xu, L Li, F Qian… - … Applied Materials & …, 2023 - ACS Publications
Aerobic glycolysis is the primary energy supply mode for glioblastoma (GBM) cells to
maintain growth and proliferation. However, due to the metabolic reprogramming of tumor …

[HTML][HTML] MiRNAs action and impact on mitochondria function, metabolic reprogramming and chemoresistance of cancer cells: a systematic review

D Rosolen, E Nunes-Souza, R Marchi, MV Tofolo… - Biomedicines, 2023 - mdpi.com
MicroRNAs (miRNAs) are involved in the regulation of mitochondrial function and
homeostasis, and in the modulation of cell metabolism, by targeting known oncogenes and …

Gambogenic acid inhibits proliferation and ferroptosis by targeting the miR‐1291/FOXA2 and AMPKα/SLC7A11/GPX4 axis in colorectal cancer

X Ma, M Xu, X Zhang, X Wang, K Su, Z Xu… - Cell Biology …, 2023 - Wiley Online Library
The present study aims to investigate the mechanism of the nature compound gambogenic
acid (GNA) on the apoptosis and ferroptosis in colorectal cancer (CRC). The effect of GNA …

[HTML][HTML] To be or not to be a fat burner, that is the question for cpt1c in cancer cells

R Fadó, S Zagmutt, L Herrero, H Muley… - Cell Death & …, 2023 - nature.com
There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis,
prognosis, and treatment of different tumor types. Described as a prognostic marker for many …

[HTML][HTML] The role of noncoding RNAs in metabolic reprogramming of cancer cells

A Safi, M Saberiyan, MJ Sanaei, S Adelian… - Cellular & Molecular …, 2023 - Springer
Metabolic reprogramming is a well-known feature of cancer that allows malignant cells to
alter metabolic reactions and nutrient uptake, thereby promoting tumor growth and spread. It …