Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease

AR Bourgonje, M Feelisch, KN Faber, A Pasch… - Trends in molecular …, 2020 - cell.com
Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …

[HTML][HTML] Role of ROS and nutritional antioxidants in human diseases

Z Liu, Z Ren, J Zhang, CC Chuang… - Frontiers in …, 2018 - frontiersin.org
The overproduction of reactive oxygen species (ROS) has been implicated in the
development of various chronic and degenerative diseases such as cancer, respiratory …

Design of diselenide-bridged hyaluronic acid nano-antioxidant for efficient ROS scavenging to relieve colitis

J Xu, T Chu, T Yu, N Li, C Wang, C Li, Y Zhang… - Acs Nano, 2022 - ACS Publications
Overproduction of reactive oxygen species (ROS), a key characteristic of inflammatory bowel
disease (IBD), is responsible for dysregulation of signal transduction, inflammatory …

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy

C Liu, X Yan, Y Zhang, M Yang, Y Ma, Y Zhang… - Journal of …, 2022 - Springer
Background Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by
diffuse inflammation of the colonic mucosa and a relapsing and remitting course. The current …

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

DK Sahoo, RM Heilmann, B Paital, A Patel… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …

Oral metal‐free melanin nanozymes for natural and durable targeted treatment of inflammatory bowel disease (IBD)

Q Huang, Y Yang, Y Zhu, Q Chen, T Zhao, Z Xiao… - Small, 2023 - Wiley Online Library
Oral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD)
treatment. To efficiently eliminate reactive oxygen species (ROS), various metal‐based …

N‐acetylcysteine: a review of clinical usefulness (an old drug with new tricks)

GK Schwalfenberg - Journal of nutrition and metabolism, 2021 - Wiley Online Library
Objective. To review the clinical usefulness of N‐acetylcysteine (NAC) as treatment or
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …

[HTML][HTML] Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets

AR Bourgonje, D Kloska, A Grochot-Przęczek… - Redox Biology, 2023 - Elsevier
Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

D Li, M Yang, H Xu, M Zhu, Y Zhang, C Tian… - Journal of Materials …, 2022 - pubs.rsc.org
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …

Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease

B Chami, NJJ Martin, JM Dennis, PK Witting - Archives of biochemistry and …, 2018 - Elsevier
Inflammatory bowel disease (IBD) is a debilitating disorder involving inflammation of the
gastrointestinal tract. The incidence of IBD is increasing worldwide. Immunological …