Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …

In eukaryotes, genomic DNA is extruded into loops by cohesin. By restraining this process,
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating …

Upon fertilization, the mammalian embryo must switch from dependence on maternal
transcripts to transcribing its own genome, and in mice this involves the transient up …

A fertilized egg is initially transcriptionally silent and relies on maternally provided factors to
initiate development. For embryonic development to proceed, the oocyte-inherited …

Expression of key transcription factors can induce transdifferentiation in somatic cells;
however, this conversion is usually incomplete due to undefined intrinsic barriers. Here, we …

Abstract CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved
protein, is known to play a critical role in chromatin structure. Post-translational modifications …

In mice, exit from the totipotent two-cell (2C) stage embryo requires silencing of the 2C-
associated transcriptional program. However, the molecular mechanisms involved in this …

Enhancers are short DNA sequences that activate their target promoter from a distance;
however, increasing the genomic distance between the enhancer and the promoter …

The biology of preimplantation embryo gene expression began 56 years ago with studies of
the effects of protein synthesis inhibition and discovery of changes in embryo metabolism …