The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Central obesity is associated with insulin resistance and dyslipidemia. Thus, the
mechanisms that control fat distribution and its impact on systemic metabolism have …

New therapeutic and preventative strategies are needed to address the growing obesity
epidemic. In animal models, brown adipose tissue activation and the associated heat …

Mitochondria are membrane organelles present in almost all eukaryotic cells. In addition to
their well-known role in energy production, mitochondria regulate central cellular processes …

Overfeeding of rodents leads to increased local formation of angiotensin II due to increased
secretion of angiotensinogen from adipocytes. Whereas angiotensin II promotes adipocyte …

In addition to their role in controlling water and salt homeostasis, recent work suggests that
aldosterone and mineralocorticoid receptors (MR) may be involved in adipocyte biology …

Excessive fat accumulation in the body causes overweight and obesity. To date, research
has confirmed that there are two types of adipose tissue with opposing functions: lipid …

The last decade has witnessed tremendous progress in the understanding of the
mineralocorticoid receptor (MR), its molecular mechanism of action, and its implications for …

Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process
required for maintaining body temperature. BAT is regulated by the sympathetic nervous …