The controversial role of homocysteine in neurology: from labs to clinical practice

R Moretti, P Caruso - International journal of molecular sciences, 2019 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin …

[HTML][HTML] Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia

R Obeid, W Herrmann - FEBS letters, 2006 - Elsevier
Mild to moderate hyperhomocysteinemia is a risk factor for neurodegenerative diseases.
Human studies suggest that homocysteine (Hcy) plays a role in brain damage, cognitive and …

New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose

M Nazıroğlu - Neurochemical research, 2007 - Springer
Abstract The Na+ and Ca 2+-permeable melastatin related transient receptor potential
(TRPM2) cation channels can be gated either by ADP-ribose (ADPR) in concert with Ca 2+ …

Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats

R Schmatz, CM Mazzanti, R Spanevello… - European journal of …, 2009 - Elsevier
The objective of the present study was to investigate the effect of the administration of
resveratrol (RV) on memory and on acetylcholinesterase (AChE) activity in the cerebral …

Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats

M Tuzcu, G Baydas - European journal of pharmacology, 2006 - Elsevier
Previous studies indicate that diabetes mellitus might be accompanied by a certain erosion
of brain function such as cognitive impairment. The aim of this study was to examine and …

Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain

İ Eren, M Nazıroğlu, A Demirdaş - Neurochemical research, 2007 - Springer
We investigated the effects of lamotrigine, aripiprazole and escitalopram administration and
experimental depression on lipid peroxidation (LP) and antioxidant levels in cortex of the …

When melatonin gets on your nerves: its beneficial actions in experimental models of stroke

RJ Reiter, D Tan, J Leon, Ü Kilic… - … biology and medicine, 2005 - journals.sagepub.com
This article summarizes the evidence that endogenously produced and exogenously
administered melatonin reduces the degree of tissue damage and limits the biobehavioral …

Homocysteine in neurology: a possible contributing factor to small vessel disease

R Moretti, M Giuffre, P Caruso, S Gazzin… - International Journal of …, 2021 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing amino acid generated during methionine
metabolism, accumulation of which may be caused by genetic defects or the deficit of …

Melatonin reduces oxidative stress induced by chronic exposure of microwave radiation from mobile phones in rat brain

D Sokolovic, B Djindjic, J Nikolic… - Journal of radiation …, 2008 - ieeexplore.ieee.org
Purpose: The aim of the study was to evaluate the intensity of oxidative stress in the brain of
animals chronically exposed to mobile phones and potential protective effects of melatonin …

[HTML][HTML] The therapeutic potential of melatonin: a review of the science

S Malhotra, G Sawhney, P Pandhi - Medscape General Medicine, 2004 - ncbi.nlm.nih.gov
Melatonin is a ubiquitous natural neurotransmitter-like compound produced primarily by the
pineal gland. This agent is involved in numerous aspects of the biological and physiologic …