The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …

Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …

Life is characterized by a myriad of complex dynamic processes allowing organisms to grow,
reproduce, and evolve. Physical approaches for describing systems out of thermodynamic …

INTRODUCTION Embedded controllers enable complex functionality in man-made
mechanical and electronic devices. Similarly, intricate regulatory networks within living …

Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …

The essential introduction to the principles and applications of feedback systems—now fully
revised and expanded This textbook covers the mathematics needed to model, analyze, and …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

The engineering of genetic circuits with predictive functionality in living cells represents a
defining focus of the expanding field of synthetic biology. This focus was elegantly set in …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …