Recent progress in the development of liver fluke and blood fluke vaccines

DP McManus - Vaccines, 2020 - mdpi.com
Liver flukes (Fasciola spp., Opisthorchis spp., Clonorchis sinensis) and blood flukes
(Schistosoma spp.) are parasitic helminths causing neglected tropical diseases that result in …

Human and animal fascioliasis: origins and worldwide evolving scenario

S Mas-Coma, MA Valero… - Clinical microbiology …, 2022 - Am Soc Microbiol
Fascioliasis is a plant-and waterborne zoonotic parasitic disease caused by two trematode
species:(i) Fasciola hepatica in Europe, Asia, Africa, the Americas, and Oceania and (ii) F …

Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity

CM Rohr, DJ Sprague, SK Park… - Proceedings of the …, 2023 - National Acad Sciences
The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other
infections caused by parasitic flatworms. A schistosome target for PZQ was recently …

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance

NJ Beesley, K Cwiklinski, K Allen, RC Hoyle… - PLoS …, 2023 - journals.plos.org
Fasciola hepatica infection is responsible for substantial economic losses in livestock
worldwide and poses a threat to human health in endemic areas. The mainstay of control in …

Insights into Fasciola hepatica juveniles: crossing the fasciolosis rubicon

J González-Miguel, D Becerro-Recio… - Trends in …, 2021 - cell.com
Unraveling the molecular interactions governing the first contact between parasite and host
tissues is of paramount importance to the development of effective control strategies against …

Paleobiogeographical origins of Fasciola hepatica and F. gigantica in light of new DNA sequence characteristics of F. nyanzae from hippopotamus

MD Bargues, A Halajian, P Artigas… - Frontiers in Veterinary …, 2022 - frontiersin.org
Fascioliasis is a highly pathogenic disease affecting humans and livestock worldwide. It is
caused by the liver flukes Fasciola hepatica transmitted by Galba/Fossaria lymnaeid snails …

Omics tools enabling vaccine discovery against fasciolosis

K Cwiklinski, JP Dalton - Trends in Parasitology, 2022 - cell.com
In the past decade significant advances in our understanding of liver fluke biology have
been made through in-depth interrogation and analysis of evolving Fasciola hepatica and …

Towards the comprehension of fasciolosis (re-) emergence: an integrative overview

A Alba, AA Vazquez, S Hurtrez-Boussès - Parasitology, 2021 - cambridge.org
The increasing distribution and prevalence of fasciolosis in both human and livestock are
concerning. Here, we examine the various types of factors influencing fasciolosis …

On the arrival of fasciolosis in the Americas

AA Vázquez, A Alba, P Alda, M Vittecoq… - Trends in …, 2022 - cell.com
Fasciola hepatica is a worldwide emerging and re-emerging parasite heavily affecting
several regions in South America. Some lymnaeid snail species of American origin are …

Lymnaeid snails and the transmission of fasciolosis: understanding the differential risks from local to global scale

AA Vázquez, A Alba, P Alda, M Vittecoq… - The Lymnaeidae: A …, 2023 - Springer
The family Lymnaeidae is globally recognized for its role in the transmission of fasciolosis.
This chapter thoroughly reviews the species of lymnaeid snails that have a proven or …