The human Y chromosome harbors genes that are responsible for testis development and
also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y …

The molecular diagnosis of Y‐chromosomal microdeletions is a common routine genetic test
which is part of the diagnostic workup of azoospermic and severe oligozoospermic men …

Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …

Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …

The Y chromosome harbors a number of genes essential for testis development and
function. Its highly repetitive structure predisposes this chromosome to deletion/duplication …

Abstract Approximately 10%–15% of couples are infertile, and a male factor is involved in
almost half of these cases. This observation is due in part to defects in spermatogenesis …

Infertility in humans is surprisingly common occurring in approximately 15% of the
population wishing to start a family. Despite this, the molecular and genetic factors …

BACKGROUND Successful gametogenesis requires the establishment of an appropriate
epigenetic state in developing germ cells. Nevertheless, an association between abnormal …

Highlights•During ART treatment, gametes and embryos are exposed to non-physiological
processes.•The short-and long-term safety of assisted reproduction is of concern.•There is …

We explain environmental and genetic factors determining male genetic conditions and
infertility and evaluate the significance of environmental stressors in shaping defensive …