Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

G Livingston, J Huntley, KY Liu, SG Costafreda… - The Lancet, 2024 - thelancet.com
Executive summary The 2024 update of the Lancet Commission on dementia provides new
hopeful evidence about dementia prevention, intervention, and care. As people live longer …

[HTML][HTML] Virtual reality and cognitive rehabilitation for older adults with mild cognitive impairment: A systematic review

C Tortora, A Di Crosta, P La Malva, G Prete… - Ageing Research …, 2024 - Elsevier
Virtual Reality (VR) has been gaining increasing attention as a potential ecological and
effective intervention system for treating Mild Cognitive Impairment (MCI). However, it …

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

S Moguilner, S Baez, H Hernandez, J Migeot… - Nature medicine, 2024 - nature.com
Brain clocks, which quantify discrepancies between brain age and chronological age, hold
promise for understanding brain health and disease. However, the impact of diversity …

Association of age at menopause and hormone therapy use with tau and β-amyloid positron emission tomography

GT Coughlan, TJ Betthauser, R Boyle… - JAMA …, 2023 - jamanetwork.com
Importance Postmenopausal females represent around 70% of all individuals with
Alzheimer disease. Previous literature shows elevated levels of tau in cognitively …

[HTML][HTML] Sex and gender in health research: Intersectionality matters

S Subramaniapillai, LAM Galea, G Einstein… - Frontiers in …, 2024 - Elsevier
Research policies aiming to integrate sex and gender in scientific studies are receiving
increased attention in academia. Incorporating these policies into health research is …

Sex and gender differences in Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis: A narrative review

A Nicoletti, R Baschi, CE Cicero, S Iacono… - Mechanisms of ageing …, 2023 - Elsevier
Abstract Neurodegenerative diseases (NDs), including Alzheimer's disease (AD),
Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), exhibit high phenotypic …

Latent profiles of modifiable dementia risk factors in later midlife: relationships with incident dementia, cognition, and neuroimaging outcomes

LY Xiong, M Wood Alexander, YY Wong, CY Wu… - Molecular …, 2024 - nature.com
Abstract In 2020, the Lancet Commission identified 12 modifiable factors that increase
population-level dementia risk. It is unclear if these risk factors co-occur among individuals …

Global burden of dementia in younger people: an analysis of data from the 2021 Global Burden of Disease Study

Z Li, Y Yang, Y Liu, X Wang, F Ping, L Xu… - …, 2024 - thelancet.com
Background Dementia among younger people is rapidly emerging as a global health
concern; however, comprehensive research on its shifting burden trends remains …

Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology

C Vila-Castelar, M Akinci, E Palpatzis… - Molecular …, 2024 - nature.com
Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD)
pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) …

[HTML][HTML] Sex differences in frailty among older adults

RS Zeidan, T McElroy, L Rathor, MS Martenson… - Experimental …, 2023 - Elsevier
By definition, aging is a natural, gradual and continuous process. On the other hand, frailty
reflects the increase in vulnerability to stressors and shortens the time without disease …