Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as
cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term …

Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets …

The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative
condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in …

Cerebral blood flow (CBF) reductions in Alzheimer's disease patients and related mouse
models have been recognized for decades, but the underlying mechanisms and resulting …

Early in Alzheimer's disease (AD), pericytes constrict capillaries, increasing their hydraulic
resistance and trapping of immune cells and, thus, decreasing cerebral blood flow (CBF) …

Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich
foods significantly improve cognitive capabilities, inhibit or delay the senescence process …

For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases
(NOX) was synonymous with NOX2/gp91phox and was considered to be a peculiarity of …