Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Inflammatory bowel diseases (IBDs), represented by Crohn disease and ulcerative colitis,
are associated with major morbidity in Western countries and with increasing incidence in …

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play
important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is …

Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also
has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases …

Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …

Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the
gastrointestinal tract with extraintestinal manifestations and associated immune disorders …

BACKGROUND & AIMS: Interactions between genetic and environmental factors are
believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed …

This review explores our current understanding of the complex interaction between
environmental risk factors, genetic traits and the development of inflammatory bowel …

The human gut microbiota comprises approximately 100 trillion microbial cells and has a
significant effect on many aspects of human physiology including metabolism, nutrient …

Background Presence of intestinal microbes is a prerequisite for the development of
ulcerative colitis (UC), although deviation of the normal intestinal microbiota composition …