Psoriatic arthritis (PsA) is a chronic, systemic inflammatory disease. Up to 40% of patients
with psoriasis will go on to develop PsA, usually within 5–10 years of cutaneous disease …

Objectives To review the pathophysiology, co-morbidities, and therapeutic options for
psoriasis, psoriatic arthritis and rheumatoid arthritis in order to further understand the …

The occurrence of arthritis in patients with psoriasis has been recognized since the 19th
century. However, psoriatic arthritis (PsA) was identified as a distinct entity primarily as a …

Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in
the pathogenesis of several diseases. Its encoding gene is located in the short arm of …

Psoriatic arthritis (PsA) is a chronic inflammatory disease belonging to the family of
spondyloarthropathies (SpA). PsA commonly aggravates psoriasis of the skin and frequently …

Observational cohorts have emerged as important resources to study course and prognosis
of chronic disease, and also facilitate phenotype definition for genetic studies. We describe …

Abstract Tumor Necrosis Factor (TNF)-α, is a paracrine inhibitor of melanocytes, which plays
a critical role in the pathogenesis of several autoimmune diseases including vitiligo, as …

The tumor necrosis factor-α (TNF-α) gene has been proposed as a major candidate gene in
psoriatic arthritis (PsA). TNF-α is a therapeutic target for patients responding poorly to …

Genetic epidemiological studies have demonstrated a significant genetic basis to both
psoriasis and psoriatic arthritis (PsA). Although candidate gene association studies had …

Psoriasis and psoriatic arthritis (PsA) both have substantive genetic determinants.
Numerous candidate regions and genes have now been replicated in disease susceptibility …