Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a
leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to …

Physical activity in general and sports in particular, is a mechanism that produces stress and
generates great force in the tendon and in the muscle-tendon unit, which increases the risk …

Frequent development of resistance to chemotherapeutic agents such as 5-flourouracil (5-
FU) complicates the treatment of advanced colorectal cancer (CRC). Resveratrol is able to …

Background: Tumor microenvironment (TME) is one of the most important factors in tumor
aggressiveness, with an active exchange between tumor and other TME-associated cells …

Chronic diseases including cancer have high case numbers as well as mortality rates. The
efficient treatment of chronic diseases is a major ongoing medical challenge worldwide …

Tendinitis (tendinopathy) is a pro-inflammatory and painful tendon disease commonly linked
with mechanical overuse and associated injuries, drug abuse, and lifestyle factors (including …

Tendon is a connective tissue that produces movement by transmitting the force produced
by muscle contraction to the bones. Most tendinopathy is caused by prolonged overloading …

Introduction Osteoarthritis (OA) is associated with excessive cartilage degradation,
inflammation, and decreased autophagy. Insufficient efficacy of conventional monotherapies …

Both acute and chronic tendon injuries are the most frequently occurring musculoskeletal
diseases in human and veterinary medicine, with a limited repertoire of successful and …

We reported that a 31-amino-acid Zfra protein (z inc f inger-like protein that r egulates a
poptosis) blocks neurodegeneration and cancer growth. Zfra binds WW domain-containing …