Ovarian cancer is a complex disease, mostly observed in postmenopausal women, and is
associated with poor survival rates. It is the sixth most common cancer and the fifth most …

Simple Summary Cervical cancer is the fourth leading cause of cancer-related deaths in
females worldwide. Despite an active immunisation strategy in many countries, high-risk …

Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …

Cancer risk is determined by a complex interplay of environmental and heritable factors.
Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be …

Background Genetic and lifestyle factors are associated with cancer risk. We investigated
the benefits of adhering to lifestyle advice by the World Cancer Research Fund (WCRF) with …

Purpose Polygenic risk influences susceptibility to cancer. We assessed whether polygenic
risk scores could be used in conjunction with other predictors of future disease status in cost …

Polygenic risk scores (PRS) for prostate cancer incidence have been proposed to optimize
prostate cancer screening. Prediction of lethal prostate cancer is key to any stratified …

Polygenic risk scores (PRS) leverage the genetic contribution of an individual's genotype to
a complex trait by estimating disease risk. Traditional PRS prediction methods are …

Early identification of genetic risk factors for complex diseases can enable timely
interventions and prevent serious outcomes, including mortality. While the genetics …

Endometrial cancer is a common gynaecological cancer with increasing incidence and
mortality. In the last decade, endometrial cancer genome-wide association studies (GWAS) …