Lacunar infarcts represent one of the most frequent subtypes of ischemic strokes and may
represent the first recognizable manifestation of a progressive disease of the small …

Parkinson's disease (PD) is one of the most common degenerative brain disorders caused
by the loss of dopaminergic neurons in the substantia nigra (SN). Lewy bodies and …

Background: The cause of cerebral small vessel disease is not fully understood, yet it is
important, accounting for about 25% of all strokes. It also increases the risk of having …

Background and Purpose—Total homocysteine (tHcy) levels are associated with secondary
vascular events and mortality after stroke. The aim of this study was to investigate whether …

Current evidence suggests that hydrogen sulfide (H2S) plays an important role in brain
functions, probably acting as a neuromodulator as well as an intracellular messenger. In the …

Background: The findings on the association between elevated plasma homocysteine levels
and the risk of the trial of org 10172 in acute stroke treatment (TOAST) of ischemic stroke …

Context Elevated prenatal homocysteine level is a plausible risk factor for schizophrenia
because of its partial antagonism ofN-methyl-D-aspartate receptors under physiologic …

Up to a third of strokes are rendered cryptogenic or of undetermined etiology. This number is
specifically higher in younger patients. At times, inadequate diagnostic workups, multiple …

Hyperhomocysteinemia or systemic elevation of the amino acid homocysteine is a common
metabolic disorder that is considered to be a risk factor for ischemic stroke. However, it is still …

Background and Purpose—Homocysteine is an endothelial toxin and elevated levels have
been associated with stroke risk. Stroke, particularly the small vessel disease (SVD) …