Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …

Increased rostral anterior cingulate cortex (rACC) activity has emerged as a promising
predictor of treatment response in depression, but neither the reliability of this relationship …

Background: Treatment of major depression with antidepressants is generally associated
with a delay in onset of clinical response. Functional brain correlates of this phenomenon …

OBJECTIVE: Administration of placebo can result in a clinical response indistinguishable
from that seen with active antidepressant treatment. Functional brain correlates of this …

This paper reports the results of an across lab metanalysis of effective connectivity in major
depression (MDD). Using FDG PET data and Structural Equation Modeling, a formal …

In this fully-revised fourth edition of what has long been the standard textbook for the field,
Dr. Richard Abrams once again demonstrates his unique ability to analyze and present a …

Although rTMS is moving steadily into the mainstream as a treatment for medically refractory
depression, its efficacy continues to lag behind that of more invasive neuromodulation …

Magnetic seizure therapy (MST) is a novel means of performing convulsive therapy using
rapidly alternating strong magnetic fields. MST offers greater control of intracerebral current …

Objectives Electroconvulsive therapy (ECT) is a well-established effective treatment strategy
in treatment-refractory depression. However, despite ECT's widespread use, the exact …

Background Although the clinical efficacy of electroconvulsive therapy (ECT) is well
established, the underlying mechanisms of action remain elusive. The aim of this study was …