Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …

Natural products have inspired chemists and physicians for millennia. Their rich structural
diversity and complexity has prompted synthetic chemists to produce them in the laboratory …

Vancomycin and teicoplanin are the two glycopeptide antibiotics that are used clinically, and
the emergence of resistance to them poses a serious threat to human health. Some …

Bleomycins are a family of glycopeptide antibiotics that have potent antitumour activity
against a range of lymphomas, head and neck cancers and germ-cell tumours. The …

Polyketide (PK) and nonribosomal peptides (NRP), constructed on multimodular enzymatic
assembly lines, often attain the conformations that establish biological activity by cyclization …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Appreciation that some cyclic peptide antibiotics such as gramicidin S and tyrocidine were
nonribosomally synthesized has been known for 50 years. The past two decades of …

Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

Glycopeptides such as vancomycin, teicoplanin and telavancin are essential for treating
infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new …