Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …

Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain
regions of a large population of human participants facilitates in vivo study of localized or …

Psychiatric disorders are one of the leading causes of disability worldwide and affect the
quality of life of both individuals and the society. The current understanding of these …

Background In terms of antipsychotic treatment response, patients with schizophrenia can
be classified into three groups: 1) treatment resistant to both non-clozapine (non-CLZ) …

Schizophrenia is a severe and clinically heterogenous mental disorder affecting
approximately 1% of the population worldwide. Despite tremendous achievements in the …

The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

Background Glutathione [GSH] is a major intracellular antioxidant that disposes peroxides
and protects neurons and glial cells from oxidative stress. In both schizophrenia and bipolar …