Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis

FD Ni, SL Hao, WX Yang - Cell death & disease, 2019 - nature.com
The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

Nanomaterials disrupting cell-cell junctions towards various diseases

S Xu, X Pang, X Zhang, Q Lv, M Zhang, J Wang, N Ni… - Nano Research, 2023 - Springer
As the continuous development of the industrial revolution, nanomaterials with excellent
characteristics have been widely applied in various fields, greatly increasing the probability …

The simultaneous administration of microplastics and cadmium alters rat testicular activity and changes the expression of PTMA, DAAM1 and PREP

M Venditti, M Ben Hadj Hassine, I Messaoudi… - Frontiers in Cell and …, 2023 - frontiersin.org
This paper confirms the damaging effects produced by MP and Cd on testicular activity in the
rat. Oral treatment with both chemicals resulted in testicular damage, documented by …

Generation of a highly biomimetic organoid, including vasculature, resembling the native immature testis tissue

TC Cham, F Ibtisham, MA Fayaz, A Honaramooz - Cells, 2021 - mdpi.com
The creation of a testis organoid (artificial testis tissue) with sufficient resemblance to the
complex form and function of the innate testis remains challenging, especially using non …

Deoxynivalenol induced spermatogenesis disorder by blood-testis barrier disruption associated with testosterone deficiency and inflammation in mice

Z Cao, W Huang, Y Sun, Y Li - Environmental pollution, 2020 - Elsevier
Deoxynivalenol (DON) is an unavoidable cereal crops contaminants and environmental
pollutants, which seriously threated the health of human and animal. DON has been …

Altered expression of DAAM1 and PREP induced by cadmium toxicity is counteracted by melatonin in the rat testis

M Venditti, M Ben Rhouma, MZ Romano, I Messaoudi… - Genes, 2021 - mdpi.com
Cadmium (Cd) is one of the most toxic pollutants for health due to its accumulation in several
tissues, including testis. This report confirms that Cd increased oxidative stress and …

Single-cell transcriptomic dissection of the toxic impact of di (2-ethylhexyl) phthalate on immature testicular development at the neonatal stage

Y Wei, Y Hong, L Yang, J Wang, T Zhao… - Food and Chemical …, 2023 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) early exposure leads to immature testicular
injury, and we aimed to utilize single-cell RNA (scRNA) sequencing to comprehensively …

The potential of sertoli cells (SCs) derived exosomes and its therapeutic efficacy in male reproductive disorders

N Amiri, P Mohammadi, A Allahgholi, F Salek, E Amini - Life Sciences, 2023 - Elsevier
In the male reproductive system, seminiferous tubules in testis are lined by a complex
stratified epithelium containing two distinct populations of cells, spermatogenic cells that …

Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events

Y Li, M Dong, Y Xiong, Q Chang, X Chen, X Fu, X Li… - Archives of …, 2022 - Springer
Whether or not tetrabromobisphenol A (TBBPA) has reproductive developmental toxicity
remains controversial. Here, we evaluated the effects of postnatal TBBPA exposure of dams …

A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male …

X Meng, H Peng, Y Ding, L Zhang, J Yang… - Science of The Total …, 2019 - Elsevier
Microcystin-leucine arginine (MC-LR) which is produced by cyanobacteria is a potent toxin
for the reproductive system. Our previous work has demonstrated that both acute and …