Purpose.: Lipofuscin (LF) and melanolipofuscin (MLF) of the retinal pigment epithelium
(RPE) are the principal sources of autofluorescence (AF) signals in clinical fundus–AF …

The retinal pigment epithelium (RPE) is an important monolayer of cells present in the outer
retina, forming a major part of the blood–retina barrier (BRB). It performs many tasks …

Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment
epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes …

Autophagy regulates cellular homeostasis and response to environmental stress. Within the
retinal pigment epithelium (RPE) of the eye, the level of autophagy can change with both …

Age-related macular degeneration (AMD) is a multifactorial neurodegenerative disorder.
Although molecular mechanisms remain elusive, deficits in autophagy have been …

Retinal pigment epithelium (RPE) dysfunction and atrophy occur in dry age-related macular
degeneration (AMD), often leading to photoreceptor degeneration and vision loss …

The retinal pigment epithelium (RPE) is a particularly vulnerable tissue to age-dependent
degeneration. Over the lifespan, the RPE develops an expanded endo-lysosomal …

While increased VEGF‐A has been associated with neovascular age‐related macular
degeneration (AMD), it is not known whether VEGF‐A may also promote other age‐related …

Myopia, which prevalence is rapidly increasing, causes visual impairment; however, the
onset mechanism of pathological axial length (AL) elongation remains unclear. A highly …

The retinal pigment epithelium (RPE) provides vital metabolic support for retinal
photoreceptor cells and is an important player in numerous retinal diseases. Gene …