Microglia play numerous important roles in brain development. From early embryonic stages
through adolescence, these immune cells influence neuronal genesis and maturation, guide …

Research into Alzheimer's Disease (AD) describes a link between AD and the resident
immune cells of the brain, the microglia. Further, this suspected link is thought to have …

Microglia have an innate immunity memory (IIM) with divergent functions in different animal
models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is …

Alzheimer's disease (AD) is a neurodegenerative disorder influenced by a complex interplay
of environmental, epigenetic, and genetic factors. DNA methylation (5mC) and …

Early-life adversity (ELA) is known to alter brain circuit maturation as well as increase
vulnerability to cognitive and emotional disorders. However, the importance of examining …

Alzheimer's disease (AD) is the most common neurodegenerative disease. Most cases of
AD are considered idiopathic and likely due to a combination of genetic, environmental, and …

Early life stress (ELS) can negatively impact health, increasing the risk of stress-related
disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD …

Over the past decades, significant efforts have been made to understand the precise
mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common …

Neuropsychiatric symptoms (NPS) such as depression, anxiety, apathy and aggression
affect up to 90% of Alzheimer's disease (AD) patients. These symptoms significantly …

Stress exposure during the sensitive period of early development has been shown to
program the brain and increases the risk to develop cognitive deficits later in life. We have …