Modulatory effects of probiotics during pathogenic infections with emphasis on immune regulation

A Raheem, L Liang, G Zhang, S Cui - Frontiers in immunology, 2021 - frontiersin.org
In order to inhibit pathogenic complications and to enhance animal and poultry growth,
antibiotics have been extensively used for many years. Antibiotics applications not only …

Salmonella Typhimurium diarrhea reveals basic principles of enteropathogen infection and disease-promoted DNA exchange

SY Wotzka, BD Nguyen, WD Hardt - Cell host & microbe, 2017 - cell.com
Despite decades of research, efficient therapies for most enteropathogenic bacteria are still
lacking. In this review, we focus on Salmonella enterica Typhimurium (S. Typhimurium), a …

[HTML][HTML] A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection

A Jacobson, L Lam, M Rajendram, F Tamburini… - Cell host & …, 2018 - cell.com
The intestinal microbiota provides colonization resistance against pathogens, limiting
pathogen expansion and transmission. These microbiota-mediated mechanisms were …

Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

E Bakkeren, JS Huisman, SA Fattinger, A Hausmann… - Nature, 2019 - nature.com
The emergence of antibiotic-resistant bacteria through mutations or the acquisition of
genetic material such as resistance plasmids represents a major public health issue …

[HTML][HTML] Critical role for the microbiota in CX3CR1+ intestinal mononuclear phagocyte regulation of intestinal T cell responses

M Kim, C Galan, AA Hill, WJ Wu, H Fehlner-Peach… - Immunity, 2018 - cell.com
The intestinal barrier is vulnerable to damage by microbiota-induced inflammation that is
normally restrained through mechanisms promoting homeostasis. Such disruptions …

[HTML][HTML] Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

SA Fattinger, P Geiser, PS Ventayol, ML Di Martino… - Mucosal …, 2021 - Elsevier
The gut epithelium is a critical protective barrier. Its NAIP/NLRC4 inflammasome senses
infection by Gram-negative bacteria, including Salmonella Typhimurium (S. Tm) and …

[HTML][HTML] Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes

SM Crowley, X Han, JM Allaire, M Stahl, I Rauch… - PLoS …, 2020 - journals.plos.org
We investigated the role of the inflammasome effector caspases-1 and-11 during
Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells …

The bactericidal lectin RegIIIβ prolongs gut colonization and enteropathy in the streptomycin mouse model for Salmonella diarrhea

T Miki, R Goto, M Fujimoto, N Okada, WD Hardt - Cell host & microbe, 2017 - cell.com
The bactericidal lectin RegIIIβ is inducibly produced by intestinal epithelial cells as a
defense against infection by enteropathogens. In the gut lumen, RegIIIβ kills not only certain …

Association of Heterophil/Lymphocyte Ratio with Intestinal Barrier Function and Immune Response to Salmonella enteritidis Infection in Chicken

M Thiam, AL Barreto Sánchez, J Zhang, M Zheng… - Animals, 2021 - mdpi.com
Simple Summary Salmonella represents a serious threat to the poultry industry and human
health. The heterophil/lymphocyte (H/L) ratio indicates the robustness and immune system …

Recurrent infection progressively disables host protection against intestinal inflammation

WH Yang, DM Heithoff, PV Aziz, M Sperandio, V Nizet… - Science, 2017 - science.org
INTRODUCTION Foodborne infections represent a serious and increasing human health
problem while at the same time the incidence and prevalence of colitis and the inflammatory …