Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application
J Xie, Y Bi, H Zhang, S Dong, L Teng, RJ Lee… - Frontiers in …, 2020 - frontiersin.org
Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …
been predominantly used in basic and preclinical research during the last 30 years. Since …
Nanoparticles for targeted brain drug delivery: what do we know?
RGR Pinheiro, AJ Coutinho, M Pinheiro… - International Journal of …, 2021 - mdpi.com
The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and
possesses unique characteristics that make the delivery of drugs to the brain a great …
possesses unique characteristics that make the delivery of drugs to the brain a great …
Internalization mechanisms of cell-penetrating peptides
I Ruseska, A Zimmer - Beilstein journal of nanotechnology, 2020 - beilstein-journals.org
In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …
Understanding cell penetration of cyclic peptides
Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives
AFL Schneider, M Kithil, MC Cardoso, M Lehmann… - Nature Chemistry, 2021 - nature.com
Enabling the cellular delivery and cytosolic bioavailability of functional proteins constitutes a
major challenge for the life sciences. Here we demonstrate that thiol-reactive arginine-rich …
major challenge for the life sciences. Here we demonstrate that thiol-reactive arginine-rich …
Cell penetrating peptides as molecular carriers for anti-cancer agents
A Borrelli, AL Tornesello, ML Tornesello… - Molecules, 2018 - mdpi.com
Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …
of molecular exchanges between the cytosol and the extracellular environment as the …
Cell-penetrating peptides: breaking through to the other side
E Koren, VP Torchilin - Trends in molecular medicine, 2012 - cell.com
Cell-penetrating peptides (CPPs) have been previously shown to be powerful transport
vector tools for the intracellular delivery of a large variety of cargoes through the cell …
vector tools for the intracellular delivery of a large variety of cargoes through the cell …
Applications and challenges for use of cell-penetrating peptides as delivery vectors for peptide and protein cargos
The hydrophilic nature of peptides and proteins renders them impermeable to cell
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …
Discovery and mechanism of highly efficient cyclic cell-penetrating peptides
Previous cell-penetrating peptides (CPPs) generally have low cytosolic delivery efficiencies,
because of inefficient endosomal escape. In this study, a family of small, amphipathic cyclic …
because of inefficient endosomal escape. In this study, a family of small, amphipathic cyclic …
Mechanisms of cellular uptake of cell‐penetrating peptides
F Madani, S Lindberg, Ü Langel, S Futaki… - Journal of …, 2011 - Wiley Online Library
Recently, much attention has been given to the problem of drug delivery through the cell‐
membrane in order to treat and manage several diseases. The discovery of cell penetrating …
membrane in order to treat and manage several diseases. The discovery of cell penetrating …