Salt sensitivity refers to the physiological trait present in mammals, including humans, by
which the blood pressure (BP) of some members of the population exhibits changes parallel …

Salt resistance/sensitivity refers specifically to the effect of dietary sodium chloride (salt)
intake on BP. Increased dietary salt intake promotes an early and uniform expansion of …

The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain
incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF …

Objective. Recent studies in animal models and on human cells have shown an effect of
sodium chloride (NaCl) on Th17 cells promoting inflammation. The aim of this study was to …

Animal and human studies support an untoward effect of excess dietary NaCl (salt) intake on
cardiovascular and renal function and life span. Recent work has promoted the concept that …

RESULTS: Systolic and diastolic BP measurements of patients were similar in the three salt-
intake groups. CRP and urinary albumin levels were significantly higher in high-salt-intake …

The controversial issue of the relationship between dietary NaCl (referred to as “salt” in this
article) intake and health was framed nicely in the superb review by Prof Eberhard Ritz. 1 …

High salt (HS) intake stimulates the production of marinobufagenin (MBG), an endogenous
steroidal Na/K-ATPase ligand, which activates profibrotic signaling. HS is accompanied by a …

The renal proximal tubule metabolizes circulating low-molecular-weight proteins such as Ig
free light chains. In the setting of plasma cell dyscrasias, the burden of filtered protein can be …

Preclinical studies point to a key role for cytokines in hypertension via their actions in the
kidney. Consistent with this notion, anti-inflammatory therapies can attenuate BP elevation in …