Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …

Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat
as a defense against cold and excessive feeding. Interest in the field of BAT biology has …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

The uniqueness of UCP1 (as compared to UCP2/UCP3) is evident from expression analysis
and ablation studies. UCP1 expression is positively correlated with metabolic inefficiency …

Obesity, ie an excess of white adipose tissue (WAT), predisposes to the development of type
2 diabetes and cardiovascular disease. Brown adipose tissue is present in rodents but not in …

Obesity results from an imbalance in energy homeostasis, whereby excessive energy intake
exceeds caloric expenditure. Energy can be dissipated out of an organism by producing …

Fibroblast growth factor 21 (FGF21) has multiple metabolic actions, including the induction
of browning in white adipose tissue. Although FGF21 stimulated browning results from a …

Omega-3 PUFA of marine origin reduce adiposity in animals fed a high-fat diet. Our aim was
to learn whether EPA and DHA could limit development of obesity and reduce cellularity of …

The availability of mice lacking the mitochondrial uncoupling protein UCP1, has provided an
opportunity to analyze the relationship between the capacity for energy expenditure and the …