In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …

The complement membrane attack complex (MAC) is classically known as a cytolytic effector
of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or …

In response to complement activation, the membrane attack complex (MAC) assembles from
fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a 'multi …

Complement plays an essential role in inflammation and tissue damage. However, it is
largely unknown to what extent the system acts as a primary inducer of secondary mediator …

Complement system activation plays an important role in both innate and acquired immunity.
Activation of the complement and the subsequent formation of C5b-9 channels (the …

Despite significant research on the role of inflammation and immunosurveillance in the
immunologic microenvironment of tumors, little attention has been given to the oncogenic …

Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …

Rationale: Pulmonary hypertension (PH) is a life-threatening cardiopulmonary disorder in
which inflammation and immunity have emerged as critical early pathogenic elements …

Recent insights into the role of complement anaphylatoxins C3a and C5a in cancer provide
new opportunities for the development of innovative biomarkers and therapeutic strategies …

Complement is a central component of the innate immune system involved in protection
against pathogens. For many years, complement has been known to cause death of targets …