In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the
role of a universal metabolic fuel for energy via the 'lactate shuttle'moving between cells and …

Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3 hi GBM) show limited
benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying …

Lysine residues in histones and other proteins can be modified by post-translational
modifications that encode regulatory information. Lysine acetylation and methylation are …

Once considered as a “metabolic waste,” lactate is now recognized as a major fuel for
tricarboxylic acid (TCA) cycle. Our metabolic flux analysis reveals that skeletal muscle …

Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …

Background: Hepatocellular carcinoma (HCC) is a malignant tumor associated with high
morbidity and mortality. Therefore, it is of great importance to develop effective prognostic …

Abstract Background Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is
identified as an oncogene involved in multiple regulation of tumor progression, but specific …

Data-independent acquisition (DIA) mass spectrometry (MS) has emerged as a powerful
technology for high-throughput, accurate, and reproducible quantitative proteomics. This …