Latest developments in molecular tracers for fluorescence image-guided cancer surgery
Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …
[HTML][HTML] Emerging fluorescent molecular tracers to guide intra-operative surgical decision-making
P Debie, S Hernot - Frontiers in Pharmacology, 2019 - frontiersin.org
Fluorescence imaging is an emerging technology that can provide real-time information
about the operating field during cancer surgery. Non-specific fluorescent agents, used for …
about the operating field during cancer surgery. Non-specific fluorescent agents, used for …
Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging
Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …
Cyanine conjugate‐based biomedical imaging probes
Cyanine is a class of fluorescent dye with meritorious fluorescence properties and has
motivated numerous researchers to explore its imaging capabilities by miscellaneous …
motivated numerous researchers to explore its imaging capabilities by miscellaneous …
[HTML][HTML] Protein scaffolds: antibody alternatives for cancer diagnosis and therapy
R Luo, H Liu, Z Cheng - RSC chemical biology, 2022 - pubs.rsc.org
Although antibodies are well developed and widely used in cancer therapy and diagnostic
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …
[HTML][HTML] Exploring alternative antibody scaffolds: Antibody fragments and antibody mimics for targeted drug delivery
DA Richards - Drug Discovery Today: Technologies, 2018 - Elsevier
The field of targeted therapeutics has benefitted immeasurably from the development of high-
affinity antibodies. These important ligands have facilitated the development of effective …
affinity antibodies. These important ligands have facilitated the development of effective …
Quicker, deeper and stronger imaging: A review of tumor-targeted, near-infrared fluorescent dyes for fluorescence guided surgery in the preclinical and clinical stages
J Jiao, J Zhang, F Yang, W Song, D Han, W Wen… - European Journal of …, 2020 - Elsevier
Cancer is a public health problem and the main cause of human mortality and morbidity
worldwide. Complete removal of tumors and metastatic lymph nodes in surgery is …
worldwide. Complete removal of tumors and metastatic lymph nodes in surgery is …
Fluorescence-guided surgery of cancer: applications, tools and perspectives
Thousands of patients die each year from residual cancer that remains following
cytoreductive surgery. Use of tumor-targeted fluorescent dyes (TTFDs) to illuminate …
cytoreductive surgery. Use of tumor-targeted fluorescent dyes (TTFDs) to illuminate …
[HTML][HTML] Development and differentiation in monobodies based on the fibronectin type 3 domain
PG Chandler, AM Buckle - Cells, 2020 - mdpi.com
As a non-antibody scaffold, monobodies based on the fibronectin type III (FN3) domain
overcome antibody size and complexity while maintaining analogous binding loops …
overcome antibody size and complexity while maintaining analogous binding loops …
[HTML][HTML] Protein scaffolds in human clinics
Fundamental clinical areas such as drug delivery and regenerative medicine require
biocompatible materials as mechanically stable scaffolds or as nanoscale drug carriers …
biocompatible materials as mechanically stable scaffolds or as nanoscale drug carriers …