Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …

There is mounting urgency to find new drugs for the treatment of serious infectious diseases
and cancer that are rapidly developing resistance to previously effective drugs. One …

In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak
and its link to microcephaly and other neurological conditions, we performed a drug …

Nosocomial infections caused by fungi have increased greatly in recent years, mainly due to
the rising number of immunocompromised patients. However, the available antifungal …

The ubiquitin proteasome system (UPS) is an essential metabolic constituent of cellular
physiology that tightly regulates cellular protein concentrations with specificity and precision …

Control of fungal pathogens is increasingly problematic due to the limited number of
effective drugs available for antifungal therapy. Conventional antifungal drugs could also …

Diseases caused by fungi can occur in healthy people, but immunocompromised patients
are the major risk group for invasive fungal infections. Cases of fungal resistance and the …

Current antimicrobial susceptibility testing has limited screening capability for identifying
empirical antibiotic combinations to treat severe bacterial infections with multidrug-resistant …

Highlights⿢NPC repurposing screens discovered compounds with new clinical
indications.⿢Systematic NPC screening data establishes rich drug activity …

Fungal infections are a serious problem affecting many people worldwide, creating critical
economic and medical consequences. Fungi are ubiquitous and can cause invasive …