Apicomplexa are obligatory intracellular parasites that sense and actively invade host cells.
Invasion is a conserved process that relies on the timely and spatially controlled exocytosis …

Rhoptries are specialized secretory organelles found in the Apicomplexa phylum, playing a
central role in the establishment of parasitism. The rhoptry content includes membranous as …

Plasmodium sporozoites that are transmitted by blood-feeding female Anopheles
mosquitoes invade hepatocytes for an initial round of intracellular replication, leading to the …

Apicomplexan parasites possess secretory organelles called rhoptries that undergo
regulated exocytosis upon contact with the host. This process is essential for the parasitic …

A vaccine targeting multiple stages of the Plasmodium falciparum parasite life cycle is
desirable. The sporozoite surface Circumsporozoite Protein (CSP) is the target of leading …

Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through
the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites …

Plasmodium malaria parasites are obligate intracellular protozoans that use a unique form
of locomotion, termed gliding motility, to move through host tissues and invade cells. The …

Plasmodium sporozoites exhibit a complex infection biology in the mosquito and
mammalian hosts. The sporozoite apical secretory organelles, the micronemes and …

Apicomplexan parasites encompass diverse pathogens for humans and animals, including
the causative agents of malaria and toxoplasmosis, Plasmodium spp. and Toxoplasma …

During transmission of malaria‐causing parasites from mosquitoes to mammals,
Plasmodium sporozoites migrate rapidly in the skin to search for a blood vessel. The high …