Melanoma develops as a result of several genetic alterations, with UV radiation often acting
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …

Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

Histiocytic neoplasms are a heterogeneous group of clonal haematopoietic disorders that
are marked by diverse mutations in the mitogen-activated protein kinase (MAPK) pathway …

Uveal melanoma, a rare subset of melanoma, is the most common primary intraocular
malignancy in adults. Despite effective primary therapy, nearly 50% of patients will develop …

Abstract The RAS–RAF–MEK–ERK signalling pathway is hyperactivated in a high
percentage of tumours, most frequently owing to activating mutations of the KRAS, NRAS …

Melanoma is the most aggressive and dangerous form of skin cancer that develops from
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …

Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but
molecular characterization is not yet standard in clinical care. We implemented a biopsy …

The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours
in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive …

Uveal melanoma represents∼ 85% of all ocular melanomas and up to 50% of patients
develop metastatic disease. Metastases are most frequently localised to the liver and, as few …

Purpose To evaluate dabrafenib, a selective BRAF inhibitor, combined with trametinib, a
selective MEK inhibitor, in patients with BRAF V600–mutant metastatic colorectal cancer …