[HTML][HTML] Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
[HTML][HTML] Emerging antifungal targets and strategies
M Ivanov, A Ćirić, D Stojković - International Journal of Molecular …, 2022 - mdpi.com
Despite abundant research in the field of antifungal drug discovery, fungal infections remain
a significant healthcare burden. There is an emerging need for the development of novel …
a significant healthcare burden. There is an emerging need for the development of novel …
[HTML][HTML] Vaccines for human fungal diseases: close but still a long way to go
Despite the substantial global burden of human fungal infections, there are no approved
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …
Yeast as carrier for drug delivery and vaccine construction
Y Tan, L Chen, K Li, B Lou, Y Liu, Z Liu - Journal of Controlled Release, 2022 - Elsevier
Yeast has been employed as an effective derived drug carrier as a unicellular
microorganism. Many research works have been devoted to the encapsulation of nucleic …
microorganism. Many research works have been devoted to the encapsulation of nucleic …
[HTML][HTML] Sources of antifungal drugs
G Vanreppelen, J Wuyts, P Van Dijck, P Vandecruys - Journal of Fungi, 2023 - mdpi.com
Due to their eukaryotic heritage, the differences between a fungal pathogen's molecular
makeup and its human host are small. Therefore, the discovery and subsequent …
makeup and its human host are small. Therefore, the discovery and subsequent …
Immunity to fungi in the lung
LJ Heung, DL Wiesner, K Wang, A Rivera… - Seminars in immunology, 2023 - Elsevier
The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …
[HTML][HTML] Treatment of invasive aspergillosis: how it's going, where it's heading
Despite improvements in treatment and diagnostics over the last two decades, invasive
aspergillosis (IA) remains a devastating fungal disease. The number of …
aspergillosis (IA) remains a devastating fungal disease. The number of …
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …
Currently available antifungals include only five classes, and their utility and efficacy in …
Harnessing the immune response to fungal pathogens for vaccine development
A Rivera, J Lodge, C Xue - Annual review of microbiology, 2022 - annualreviews.org
Invasive fungal infections are emerging diseases that kill over 1.5 million people per year
worldwide. With the increase of immunocompromised populations, the incidence of invasive …
worldwide. With the increase of immunocompromised populations, the incidence of invasive …
[HTML][HTML] Vaccines against candidiasis: Status, challenges and emerging opportunity
Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of
fungal infections has considerably increased in the last few years primarily due to an …
fungal infections has considerably increased in the last few years primarily due to an …