Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …

Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

The system physiology approaches that emerge in western countries in recent years echo
the holistic view of ancient Traditional Chinese Medicine (TCM) practices that deal with the …

Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …

Depression is considered a major public health concern, where existing pharmacological
treatments are not equally effective across all patients. The pathogenesis of depression …

The gut microbiota plays a crucial role in human health and disease. Gut dysbiosis is known
to be associated with increased susceptibility to respiratory diseases and modifications in …

The precise mechanism by which gut dysbiosis contributes to the pathogenesis of
extraintestinal diseases and how commensal microbes mediate these processes remain …

Immune cell trafficking is a complex and tightly regulated process that is indispensable for
the body's fight against pathogens. However, it is also increasingly acknowledged that …

Advances in the understanding of psychoneuroimmunology in the past decade have
emphasized the notion that stress and cancer are interlinked closely. Durable chronic stress …

Gene-environment interactions shape behavior and susceptibility to depression. However,
little is known about the signaling pathways integrating genetic and environmental inputs to …