Early-onset Alzheimer disease and its variants
MF Mendez - CONTINUUM: Lifelong Learning in Neurology, 2019 - journals.lww.com
PURPOSE OF REVIEW Early-onset Alzheimer disease (AD) is defined as having an age of
onset younger than 65 years. While early-onset AD is often overshadowed by the more …
onset younger than 65 years. While early-onset AD is often overshadowed by the more …
Early-onset Alzheimer disease
MF Mendez - Neurologic clinics, 2017 - neurologic.theclinics.com
Alzheimer disease (AD) originally meant a disorder of early-onset (EOAD;< 65 years of age)
and did not include older patients with “senile dementia.” In fact, the first patient reported …
and did not include older patients with “senile dementia.” In fact, the first patient reported …
APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
Background Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …
APP, PSEN1, and PSEN2 Variants in Alzheimer's Disease: Systematic Re-evaluation According to ACMG Guidelines
X Xiao, H Liu, X Liu, W Zhang, S Zhang… - Frontiers in aging …, 2021 - frontiersin.org
The strategies of classifying APP, PSEN1, and PSEN2 variants varied substantially in the
previous studies. We aimed to re-evaluate these variants systematically according to the …
previous studies. We aimed to re-evaluate these variants systematically according to the …
[HTML][HTML] Alzheimer's Disease as Type 3 Diabetes: Understanding the Link and Implications
M Kciuk, W Kruczkowska, J Gałęziewska… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions
that present considerable public health issue in aging populations worldwide. Recent …
that present considerable public health issue in aging populations worldwide. Recent …
[HTML][HTML] Processing of mutant β-amyloid precursor protein and the clinicopathological features of familial Alzheimer's disease
C Bi, S Bi, B Li - Aging and disease, 2019 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a complex, multifactorial disease involving many pathological
mechanisms. Nonetheless, single pathogenic mutations in amyloid precursor protein (APP) …
mechanisms. Nonetheless, single pathogenic mutations in amyloid precursor protein (APP) …
Modulatory effects of fingolimod (FTY720) on the expression of sphingolipid metabolism-related genes in an animal model of Alzheimer's disease
H Jęśko, PL Wencel, WJ Lukiw… - Molecular Neurobiology, 2019 - Springer
Sphingolipid signaling disturbances correlate with Alzheimer's disease (AD) progression.
We examined the influence of FTY720/fingolimod, a sphingosine analog and sphingosine-1 …
We examined the influence of FTY720/fingolimod, a sphingosine analog and sphingosine-1 …
[HTML][HTML] The whole exome sequencing clarifies the genotype-phenotype correlations in patients with early-onset dementia
Our study aimed to identify the underlying causes in patients with early onset dementia by
clinical and genetic exploration. We recruited a group of 38 patients with early-onset …
clinical and genetic exploration. We recruited a group of 38 patients with early-onset …
Rare amyloid precursor protein point mutations recapitulate worldwide migration and admixture in healthy individuals: Implications for the study of neurodegeneration
Genetic discoveries related to Alzheimer's disease and other dementias have been
performed using either large cohorts of affected subjects or multiple individuals from the …
performed using either large cohorts of affected subjects or multiple individuals from the …
Clinical and molecular findings in a Turkish family who had a (c. 869-1G> A) splicing variant in PSEN1 gene with a rare condition: the variant alzheimer's disease with …
Background: Early-onset Alzheimer's disease (EOAD) is commonly diagnosed with an onset
age of earlier than 65 years and accounts for 5–10% of all Alzheimer's disease (AD) cases …
age of earlier than 65 years and accounts for 5–10% of all Alzheimer's disease (AD) cases …