Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …

L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …

Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

Voltage-gated ion channels (VGICs) comprise multiple structural units, the assembly of
which is required for function,. Structural understanding of how VGIC subunits assemble and …

In the heart, Ca2+ influx via CaV1. 2 L-type calcium channels (LTCCs) is a multi-functional
signal that triggers muscle contraction, controls action potential duration, and regulates gene …

The voltage-gated Ca2+ channel β subunit (Cavβ) is a cytosolic auxiliary subunit that plays
an essential role in regulating the surface expression and gating properties of high-voltage …

Ca2+ influx through high-voltage-activated calcium channels (HVACCs) controls diverse
cellular functions. A critical feature enabling a singular signal, Ca2+ influx, to mediate …

The voltage-gated K+ channel Kv2. 1 serves a major structural role in the soma and
proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to …

Voltage‐gated calcium channels (VGCCs) represent the sole mechanism to convert
membrane depolarization into cellular functions like secretion, contraction, or gene …