Genome folding through loop extrusion by SMC complexes
IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …
serve important structural and regulatory roles. It has been proposed that these genomic …
Looping the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
Real-time imaging of DNA loop extrusion by condensin
It has been hypothesized that SMC protein complexes such as condensin and cohesin
spatially organize chromosomes by extruding DNA into large loops. We directly visualized …
spatially organize chromosomes by extruding DNA into large loops. We directly visualized …
The structural basis for cohesin–CTCF-anchored loops
Y Li, JHI Haarhuis, Á Sedeño Cacciatore… - Nature, 2020 - nature.com
Cohesin catalyses the folding of the genome into loops that are anchored by CTCF. The
molecular mechanism of how cohesin and CTCF structure the 3D genome has remained …
molecular mechanism of how cohesin and CTCF structure the 3D genome has remained …
Organization of chromosomal DNA by SMC complexes
S Yatskevich, J Rhodes, K Nasmyth - Annual review of genetics, 2019 - annualreviews.org
Structural maintenance of chromosomes (SMC) complexes are key organizers of
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …
Cryo-EM structure of the human cohesin-NIPBL-DNA complex
As a ring-shaped adenosine triphosphatase (ATPase) machine, cohesin organizes the
eukaryotic genome by extruding DNA loops and mediates sister chromatid cohesion by …
eukaryotic genome by extruding DNA loops and mediates sister chromatid cohesion by …
A hold-and-feed mechanism drives directional DNA loop extrusion by condensin
IA Shaltiel, S Datta, L Lecomte, M Hassler… - Science, 2022 - science.org
Structural maintenance of chromosomes (SMC) protein complexes structure genomes by
extruding DNA loops, but the molecular mechanism that underlies their activity has …
extruding DNA loops, but the molecular mechanism that underlies their activity has …
Emerging evidence of chromosome folding by loop extrusion
Chromosome organization poses a remarkable physical problem with many biological
consequences: How can molecular interactions between proteins at the nanometer scale …
consequences: How can molecular interactions between proteins at the nanometer scale …
CTCF and R-loops are boundaries of cohesin-mediated DNA looping
Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
Human condensin I and II drive extensive ATP-dependent compaction of nucleosome-bound DNA
Structural maintenance of chromosomes (SMC) complexes are essential for genome
organization from bacteria to humans, but their mechanisms of action remain poorly …
organization from bacteria to humans, but their mechanisms of action remain poorly …