High-throughput tools for nucleic acid characterization now provide the means to conduct
comprehensive analyses of all somatic alterations in the cancer genomes. Both large-scale …

Deciphering whether actionable driver mutations are found in all or a subset of tumor cells
will likely be required to improve drug development and precision medicine strategies. We …

Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to
assess putative driver mutations identified by large-scale sequencing of human cancer …

Breast and ovarian cancer are among the most common malignancies diagnosed in women
worldwide. Together, they account for the majority of cancer-related deaths in women. These …

Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most
familial and 10% of sporadic neuroblastomas. However, the role of mutated ALK in …

Characterizing the genetic alterations leading to the more aggressive forms of oestrogen
receptor-positive (ER+) breast cancers is of critical significance in breast cancer …

High-grade serous cancer (HGSC), the most common subtype of ovarian cancer, often
becomes resistant to chemotherapy, leading to poor patient outcomes. Intratumoral …

Comprehensive genomic analyses of common nervous system cancers provide new
insights into their pathogenesis, diagnosis, and treatment. Although analogous studies of …

Loss of the DNA mismatch repair (MMR) protein MSH3 leads to the development of a variety
of tumors in mice without significantly affecting survival rates, suggesting a modulating role …

Mouse model induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) is
generally accepted as an ideal object to study on the carcinogenesis mechanisms of human …