Current medical care lacks an effective functional evaluation for the spinal cord. Magnetic
resonance imaging and computed tomography mainly provide structural information of the …

Low-molecular weight heparins (LMWH) are anticoagulants that have shown anti-
inflammatory activity in several experimental models. Hot water burn inflammatory model …

A pesar de lo cotidiano del dolor en la práctica médica y en la historia humana, el
conocimiento de su fisiología y la fisiopatología no ha sido profundizada sino sólo en los …

Calcium channel blockers, β adrenergic receptor blockers and Na/K ATPase inhibitors are
widely used drugs, mainly for cardiovascular diseases. Their pharmacological targets are …

Molecular biology investigates the genetic causes of many diseases. Currently, molecular
biology in pain research lags behind the investigations of the molecular basis of mental …

Traditional concept holds that the pain unit consists of three neurons. The first of these, the
primary nociceptive neuron, starts with the nociceptors and terminates in the dorsal spinal …

Vinpocetine, a derivate of vincamine, is widely used in the clinical pharmacotherapy of
cerebral circulatory diseases. Herewith we report on a novel effect of vinpocetine: inhibition …

En el presente estudio se caracterizó, mediante electroforesis, la expresión de proteínas y
del canal de sodio Nav1. 3, en ambas astas dorsales medulares (ADM) de rata, en …

The fluoride resistant acid phosphatase (FRAP) is considered a biomarker enzyme of
presence and function in nociceptive fibers. Its well described spinal dorsal horn (DH) …

It is well known that inhibition of Na, K-ATPase by digoxine induces an increased [Na+] i and
[Ca++] i with consequent increased cell depolarization. This effect has a potential implication …